Knockdown of miR-124 Reduces Depression-like Behavior by Targeting CREB1 and BDNF
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چکیده
منابع مشابه
MiR-124 Radiosensitizes Human Colorectal Cancer Cells by Targeting PRRX1
One of the challenges in the treatment of colorectal cancer patients is that these tumors show resistance to radiation. MicroRNAs (miRNAs) are involved in essential biological activities, including chemoresistance and radioresistance. Several research studies have indicated that miRNA played an important role in sensitizing cellular response to ionizing radiation (IR). In this study, we found t...
متن کاملMiR-124 retards bladder cancer growth by directly targeting CDK4.
MicroRNAs (miRNAs) are a class of non-coding small RNAs that act as negative regulators of gene expression by binding to the 3'-untranslated region (3'UTR) of target mRNAs. In order to investigate the physiological role of miR-124 in bladder cancer, target genes of miR-124 were predicted by the TargetScan software, and cyclin-dependent kinase (CDK4), which has been implicated as a regulator of ...
متن کاملmiR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1
miR-124 and miR-506 are reportedly down-regulated and associated with tumor progression in many cancers, but little is known about their intrinsic regulatory mechanisms in colorectal cancer (CRC). In this study, we found that the miR-124 and miR-506 levels were significantly lower in human CRC tissues than in controls, as indicated by qRT-PCR and in situ hybridization histochemistry. We also fo...
متن کاملThe microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.
miR-124, a brain-specific microRNA, was originally considered as a key regulator in neuronal differentiation and the development of the nervous system. Here we showed that miR-124 expression was suppressed in patients with epilepsy and rats after drug induced-seizures. Intrahippocampal administration of a miR-124 duplex led to alleviated seizure severity and prolonged onset latency in two rat m...
متن کاملMiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1
BACKGROUND Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression of microRNAs is widely dysregulated in ovarian cancer; and that they have ev...
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ژورنال
عنوان ژورنال: Current Neurovascular Research
سال: 2020
ISSN: 1567-2026
DOI: 10.2174/1567202617666200319141755